Symptoms of TRALI typically develop within how many hours after transfusion?

Symptoms of TRALI typically develop within how many hours after transfusion?

• A. 0-1 hours
• B. 1-6 hours
• C. 6-12 hours
• D. 12-24 hours

Answer: (B)

TRALI shows up quickly after a transfusion, typically within 1 to 6 hours. It’s an acute lung injury caused by donor antibodies or bioactive mediators that trigger neutrophil activation and capillary leak in the lungs, leading to sudden shortness of breath and low oxygen levels. Because the reaction occurs so soon after the transfusion, the 1–6 hour window captures the usual timing. Onset after 6 hours is less typical, while waiting beyond that window makes TRALI less likely as the cause.

TRALI shows up quickly after a transfusion, typically within 1 to 6 hours. It’s an acute lung injury caused by donor antibodies or bioactive mediators that trigger neutrophil activation and capillary leak in the lungs, leading to sudden shortness of breath and low oxygen levels. Because the reaction occurs so soon after the transfusion, the 1–6 hour window captures the usual timing. Onset after 6 hours is less typical, while waiting beyond that window makes TRALI less likely as the cause.